National Brain Health Platform

Large-scale college student brain health cohorts for mental health and developmental research.

This cohort resource is developed under the National Brain Health Platform and focuses primarily on student mental health, with pain, sleep, somatic symptoms, educational stress, social resources, and multimodal deep phenotyping measured as key developmental contexts.

32,296 freshman baseline students
10,113 freshman follow-up participants
22,570 COVID-era university survey wave 2
Multi-modal SCID, fMRI, actigraphy, PSG, EEG, microbiota, and related deep phenotyping

College student cohorts

College datasets with distinct sampling frames and study periods.

This page describes the college student programme. The child and adolescent cohort has its own overview and data catalogue.

Freshman Transition Cohort

A university-entry cohort with 32,296 baseline students and 10,113 follow-up participants. This cohort supports research on family and socioeconomic circumstances, pre-university residential background, university transition, depression, anxiety, sleep, pain, and somatic symptoms.

  • University-entry baseline
  • Repeated follow-up data
  • Annual recruitment and follow-up growth

COVID-era Multi-university Survey

A two-wave university student survey conducted during the COVID era. The survey includes 10,286 students in Wave 1 and 22,570 students in Wave 2, with 2,875 students observed in both waves. University-site identifiers are anonymized in the public display.

  • Wave 1: July 2020
  • Wave 2: March to June 2021
  • Multi-university sample

Freshman cohort growth

An expanding annual cohort with new recruitment and follow-up every year.

The freshman transition cohort is designed to grow each year. The next September wave is expected to include new entrants and multiple follow-up waves from previously enrolled students.

10,000+

New freshman enrollment

Expected new participants entering the cohort in September.

10,000+

First follow-up wave

Students from prior entry waves expected to complete their first follow-up.

10,000+

Second follow-up wave

Students expected to contribute repeated longitudinal measurements.

Baseline: university-entry assessment

Participants

32,296 newly enrolled college students in the current public cohort summary.

Questionnaire content

Demographics, family socioeconomic circumstances, pre-university residential background, university transition, social resources, lifestyle, sleep, mental health, pain, and somatic symptoms.

Linkage and phenotyping

Study identifiers support governed follow-up linkage. Selected participants contribute clinical interviews, imaging, activity, sleep, EEG, and biological data.

First follow-up: adaptation, exposure updates, and health outcomes

Participants

10,113 respondents in the current public summary.

Questionnaire content

Repeated core outcomes plus updated living conditions, academic experience, social support, behaviours, developmental residential history, and emerging psychosocial topics.

Linkage and phenotyping

Longitudinal linkage is available within the governed dataset. Analysis-specific linked denominators and deep-phenotyping coverage must be reported.

Next annual cycle: new recruitment and multiple follow-up waves

Expected scale

More than 10,000 new entrants and more than 10,000 participants in each active follow-up wave are expected in the next September cycle.

Questionnaire strategy

A stable longitudinal core is retained while selected modules are updated for emerging educational, social, digital, and mental-health concerns.

Deep phenotyping

Additional clinical and multimodal assessments can be nested within survey waves for mechanism-focused studies.

Cohort overview

Sample size, recruitment coverage, and baseline mental health indicators.

These descriptive summaries establish the scale and sampling context of each survey before subgroup comparisons or longitudinal modelling. Survey waves are ordered by collection period, and follow-up respondents are not counted as an additional independent cohort.

Participants by collection period

COVID-era Wave 1 · Jul 2020
10,286
COVID-era Wave 2 · Mar-Jun 2021
22,570
Freshman cohort · university-entry baseline
32,296

Counts refer to complete survey records at each collection period. The two COVID-era waves are shown separately; students appearing in both waves are not added to a unique-person total.

Depression and anxiety at initial assessment

COVID-era Wave 1
38.8 / 29.8%
COVID-era Wave 2
35.5 / 27.0%
Freshman baseline
8.0 / 5.0%

Blue = depression; orange = anxiety. Values are unadjusted screening prevalences and should not be interpreted as direct cohort comparisons because sampling periods and contexts differ.

Recruitment coverage

2020COVID-era Wave 123 universities · 32 province-level regions · 14 academic fields
2021COVID-era Wave 225 universities · 33 province-level regions · 14 academic fields
BaselineFreshman cohort2 university sites · 33 province-level regions · 14 academic fields

Coverage describes the breadth of recruitment, not national representativeness.

Participant characteristics at initial assessment

Baseline profiles are reported separately for the two college study programmes.

The Freshman Transition Cohort and COVID-era Multi-university Survey used different sampling frames and questionnaire structures. Presenting them separately preserves the meaning of each measure and avoids imposing an artificial common socioeconomic classification.

Freshman Transition Cohort

University-entry baseline

Full baseline sample; follow-up participation is described in the assessment timeline rather than counted again here.

32,296participants
50.5%female
33provinces represented
14academic disciplines

Sex

Female
16,269 · 50.5%
Male
15,949 · 49.5%

Age at baseline

18-19
26,155 · 81.7%
20-21
4,337 · 13.5%
17 or younger
1,152 · 3.6%
22-24
357 · 1.1%
25 or older
7 · 0.0%

Academic discipline

Engineering
9,770 · 30.3%
Medicine
9,319 · 28.9%
Science
3,722 · 11.6%
Other or unspecified
3,281 · 10.2%
Management
2,459 · 7.6%
Economics
2,069 · 6.4%
Literature
671 · 2.1%
Law
441 · 1.4%

Questionnaire categories translated from the original baseline codebook.

Pre-university administrative setting

County or banner
15,533 · 48.4%
Urban district
10,695 · 33.3%
County-level city
5,859 · 18.2%
Other or unclear
27 · 0.1%

Classified from reported county-level administrative unit names.

Broad geographic region

Eastern
23,436 · 72.8%
Central
5,110 · 15.9%
Western
2,642 · 8.2%
Northeastern
1,016 · 3.2%

North-south geographic grouping

Northern China
25,834 · 80.2%
Southern China
6,374 · 19.8%

Descriptive geographic grouping; not a socioeconomic classification.

Monthly household income

5,000-9,999 RMB/month
14,082 · 43.8%
<5,000 RMB/month
8,260 · 25.7%
10,000-19,999 RMB/month
7,112 · 22.1%
20,000-39,999 RMB/month
1,884 · 5.9%
40,000 RMB/month or more
825 · 2.6%

Family SES quartile

Q1 lower SES
8,511 · 26.5%
Q2
8,223 · 25.6%
Q4 higher SES
8,003 · 24.9%
Q3
7,426 · 23.1%

Complete three-component SES score available for 32,163 students.

Number of close supportive friends

3-5 friends
15,953 · 49.7%
6 or more friends
8,215 · 25.6%
1-2 friends
7,443 · 23.2%
None
514 · 1.6%

Help-seeking when distressed

Sometimes seek help
12,751 · 39.7%
Often seek help
9,537 · 29.7%
Rarely seek help
8,248 · 25.7%
Rely on oneself
1,569 · 4.9%
Additional freshman baseline characteristics

Paternal educational attainment

Middle school
13,856 · 43.0%
High school or vocational
8,051 · 25.0%
Primary school or below
3,927 · 12.2%
Bachelor's degree
3,170 · 9.8%
Junior college
2,711 · 8.4%
Graduate degree or above
476 · 1.5%

Maternal educational attainment

Middle school
13,296 · 41.3%
High school or vocational
7,393 · 23.0%
Primary school or below
5,992 · 18.6%
Bachelor's degree
2,705 · 8.4%
Junior college
2,438 · 7.6%
Graduate degree or above
366 · 1.1%

Largest provinces of pre-university residence

Hebei
13,276 · 41.2%
Shandong
8,228 · 25.5%
Anhui
1,379 · 4.3%
Jiangxi
975 · 3.0%
Hubei
881 · 2.7%
Shanxi
797 · 2.5%
Henan
651 · 2.0%
Hunan
427 · 1.3%
Shaanxi
417 · 1.3%
Jiangsu
416 · 1.3%

Top ten among valid province responses.

Sibling structure

Has siblings
24,495 · 76.1%
Only child
7,706 · 23.9%

Ethnicity

Han
30,515 · 94.7%
Other ethnic groups
1,697 · 5.3%

COVID-era Multi-university Survey

Wave 1 baseline · July 2020

The first pandemic-period survey is used for the participant profile. Wave 2 is retained in the collection timeline and longitudinal analyses, not added as a second baseline population.

10,286participants
64.4%female
23universities
32provinces represented

Sex

Female
6,624 · 64.4%
Male
3,662 · 35.6%

Age at Wave 1

20-21
6,983 · 67.9%
22-24
2,698 · 26.2%
18-19
508 · 4.9%
25 or older
86 · 0.8%
17 or younger
11 · 0.1%

Pre-university administrative setting

Urban district
4,569 · 46.5%
County or banner
3,303 · 33.6%
County-level city
1,957 · 19.9%

Broad geographic region

Central
7,753 · 75.4%
Eastern
1,325 · 12.9%
Western
1,082 · 10.5%
Northeastern
125 · 1.2%

North-south geographic grouping

Southern China
8,544 · 83.1%
Northern China
1,742 · 16.9%

Medical student status

Non-medical students
9,543 · 92.8%
Medical students
743 · 7.2%

Paternal educational attainment

Middle school
3,992 · 38.8%
High school or vocational
2,714 · 26.4%
Primary school or below
1,599 · 15.5%
Junior college
987 · 9.6%
Bachelor's degree
903 · 8.8%
Graduate degree or above
91 · 0.9%

Maternal educational attainment

Middle school
3,855 · 37.5%
Primary school or below
2,586 · 25.1%
High school or vocational
2,389 · 23.2%
Junior college
819 · 8.0%
Bachelor's degree
578 · 5.6%
Graduate degree or above
59 · 0.6%

Family/friend infection or close contact

No
10,233 · 99.5%
Yes
53 · 0.5%

Centralized quarantine experience

No
10,164 · 98.8%
Yes
122 · 1.2%

Actively sought mental health information

Yes
6,170 · 60.0%
No
4,116 · 40.0%

Received psychological intervention

No
9,865 · 95.9%
Yes
421 · 4.1%
Additional COVID-era Wave 1 characteristics

Largest provinces of pre-university residence

Hubei
6,526 · 63.4%
Henan
428 · 4.2%
Shandong
354 · 3.4%
Anhui
225 · 2.2%
Jiangxi
219 · 2.1%
Hebei
214 · 2.1%
Guizhou
201 · 2.0%
Zhejiang
197 · 1.9%
Guangxi
194 · 1.9%
Hunan
187 · 1.8%

Top ten among valid province responses.

Percentages are calculated among valid responses for each variable. Counts may therefore differ slightly across panels.

Measures collected

Core domains for student mental health and pain research.

Mental health

PHQ-9 depression symptoms, GAD-7 anxiety symptoms, psychological stress, structured clinical interviews in subsamples, and related help-seeking indicators.

Pain and somatic symptoms

Pain presence, pain severity, pain interference, somatic symptoms, and functional impact.

Sleep and lifestyle

Sleep disturbance, insomnia-related measures, physical activity, smoking, alcohol use, and other lifestyle factors.

Developmental context

Family SES, pre-university residential context, campus environment, social support, resilience, and academic satisfaction.

Questionnaire catalogue

Baseline and follow-up instruments are summarized in a public-facing questionnaire browser organized by measurement domain and assessment wave.

Open questionnaire catalogue

Deep phenotyping

Nested multimodal data can connect symptoms to mechanisms.

Beyond survey follow-up, the platform includes or is developing deep phenotyping modules in selected subsamples to support mechanistic studies of mental health, sleep, pain, and somatic distress.

Open deep phenotyping catalogue

Clinical assessment

SCID and structured clinical characterization for psychiatric phenotyping.

Neuroimaging

fMRI and related brain measures for neural correlates of symptoms and resilience.

Objective activity

One-week actigraphy / physical activity data for sleep, rhythm, and daily functioning.

Sleep physiology

PSG and EEG modules for sleep architecture and neurophysiological profiles.

Microbiota

Microbiota data to explore gut-brain, inflammation, pain, and mental-health pathways.

Survey phenotyping

Repeated measures of mental health, sleep, pain, SES, school context, support, and resilience.

Research themes

Questions the platform is designed to support.

01

Mental health trajectories

How depression, anxiety, sleep, stress, and social context change across educational transitions.

02

Pain and somatic distress

How pain, somatic symptoms, depression, anxiety, and sleep problems cluster and change over time.

03

Educational stress and transition

How university entry, academic context, major satisfaction, and school belonging shape mental health risk.

04

Developmental and socioeconomic context

How family SES, pre-university residential context, current living environment, and social support interact with student well-being.

05

Multimodal mechanisms

How clinical interviews, fMRI, activity monitoring, PSG, EEG, and microbiota can deepen cohort findings.

Collaboration

Collaborative research under appropriate ethical approvals and data-use agreements.

We welcome collaborations on student mental health, pain and somatic symptoms, sleep, developmental context, educational stress, social support, resilience, and multimodal deep phenotyping. Detailed data access is handled through project-specific agreements.

Contact the National Brain Health Platform